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Mogling Bio is developing novel pharmacological approaches to rejuvenate old stem cells. When we get old, the organization of the internal structures of blood cell forming stem cells, also called hematopoetic stem cells (HSCs), becomes disordered. This leads to an impaired production of blood and immune cells and can cause leukemia and other blood diseases.

Science

A proper function of adult stem cells is central to prevent tissue attrition and aging-associated diseases.

Cdc42 is a small RhoGTPase, and its activity is elevated in old HSCs. This causes aging of HSCs. Attenuation of elevated Cdc42 activity rejuvenates old HSCs and can extend the lifespan of mice. Mogling Bio is pursuing novel pharmaco­logical approaches to inhibit the elevated activity of Cdc42 in HSCs. Targeting the activity of Cdc42 will re-order and rejuvenate the function of old HSCs.

This approach could ameliorate aging-associated diseases like multiple myeloma and myelodysplasia syndromes and restore the aging-associated decline in the function of the immune system.

See our key publications:
https://pubmed.ncbi.nlm.nih.gov

Team

Jürgen Reeß

EXTENSIVE EXECUTIVE EXPERIENCE
CO-FOUNDER

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Yi Zheng

CDC42/CASIN EXPERT
CO-FOUNDER

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Hartmut Geiger

STEM CELL AGING AND REJUVENATION EXPERT
CO-FOUNDER

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Norbert Hauel

MEDCHEM EXPERT
INVENTOR OF TWO MOLECULES THAT BECAME BLOCKBUSTERS

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Board of Directors

Georg van Husen

EXPERIENCED PHARMA LEADER
CEO OF TENACIO

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Patrick Burgermeister

PARTNER KIZOO TECHNOLOGY VENTURES

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Jürgen Reeß

EXTENSIVE EXECUTIVE EXPERIENCE
CO-FOUNDER

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Scientific advisory board members

Jan S. Rosenbaum

EXECUTIVE EXPERT
KUROME THERAPEUTICS, CINCINNATI

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Jose Cancelas-Perez

CELL THERAPY EXPERT
HOXWORTH BLOOD CENTER AND CINCINNATI CHILDREN‘S
HOSPTIAL MEDICAL CENTER, CINCINNATI

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News/Press

Mogling Bio signs exclusive CASIN Licensing agreement

Mogling Bio entering Licensing Agreement with Cincinnati Children’s Hospital Medical Center

Kizoo invests in Rejuvenation Startup MoglingBio

Mogling Bio closes Seed Investment Round with Kizoo Technology Capital

Mogling Bio in Berlin, October 2022

Mogling Bio at the Rejuvenation Start-Up Summit in Berlin, October 14-15